Background (relevance, subject and purpose of the work): Specialized cancer care questionnaires developed for specific types of malignant neoplasms and antitumor treatments facilitate the collection of the results of patients’ self-assessment of various health related issues, including therapy outcomes. Electronic Patient Reported Outcome Measures (ePROMs) are nowadays considered as powerful tools for enforcing the introduction of remote monitoring to control acute and late radiation toxicity. The aim of this review was to exemplify and summarize the information on state-of-the-art electronic PROMs systems to follow up on the outcomes (complications, adverse events, quality of life effects, etc.) of radiation therapy in cancer patients. Methods: The PubMed database was utilised to retrieve and summarize the relevant information on the clinical trials of electronic PROMs applications to monitor the radiotherapy outcomes in cancer patients. Results. Elements of «m-health» are being developed around the world, such as PROMetheus and eRAPID. Both remote monitoring systems are showing promising results. Patient adherence to accurate data entry through electronic devices and gadgets is often higher than filling in paper forms. This work briefly and clearly represents examples of specialized oncological electronic questionnaires designed to monitor the outcomes of radiation therapy by automatically generating feedback for the patients and physicians (for instance, crucial recommendations, warnings and alert notifications etc.). Conclusions: Implementation of breakthrough developments in “mobile health care” can drastically improve or redesign the quality assurance systems to provide the highest standards of specialized cancer therapies to the community. Practical applicability of the study results: The described functional principles of the electronic PROM systems (with feedback loop) can be embedded in the platform for the further development of efficient digital healthcare services in radiation oncology.
References
1. Bennett AV, Jensen RE, Basch E. Electronic patient-reported outcome systems in oncology clinical practice. CA Cancer J Clin. 2012; 62(5): 337-347. doi:10.3322/caac.21150.
2. Digital health. World Health Organization. 2020. Available at: https://www.who.int/reproductivehealth/publications/mhealth/en/. Last accessed on : Aug 24 , 2020.
3. Advances in Patient Reported Outcomes: Integration and Innovation : Leeds, UK. 13 June 2019. J Patient Rep Outcomes. 2020; 4(1): 28. doi:10.1186/s41687-020-00193-x.
4. Niska JR, Thorpe CS, Halyard MY, Tan AD, Atherton PJ, Dueck AC et al. Patient-reported quality-of-life outcomes in relation to provider-assessed adverse events during head and neck radiotherapy. J Patient Rep Outcomes. 2020; 4(1): 60. doi:10.1186/s41687-020-00227-4.
5. DEGRO 2017: Growing demand for ePROM solutions within radio-oncology. © 2020 Kaiku Health. 2017. Available at: https://kaikuhealth.com/degro-2017-growing-demand-eprom-solutions-within-radio-oncology/. Last accessed on : Aug 20 , 2020.
6. Hauth F, Bizu V, App R, Lautenbacher H, Tenev A, Bitzer M et al. Electronic Patient-Reported Outcome Measures in Radiation Oncology: Initial Experience After Workflow Implementation. JMIR Mhealth Uhealth. 2019; 7(7): e12345. doi:10.2196/12345.
7. NCI-PRO-CTCAE™ ITEMS-RUSSIAN. Item Library Version 1.0. NATIONAL INSTITUTES OF HEALTH, in Bethesda, Maryland, U.S.A. Use of the PROCTCAE™ is subject to NCI’s Terms of Use. 2020. Available at: https://healthcaredelivery.cancer.gov/pro-ctcae/pro-ctcae_russian.pdf. Last accessed on : Aug 23 , 2020.
8. Pena-Hernandez C, Nugent K, Tuncel M. Twenty-Four-Hour Ambulatory Blood Pressure Monitoring. J Prim Care Community Health. 2020; 11:2150132720940519. doi:10.1177/2150132720940519.
9. Neibart SS, Manne SL, Jabbour SK. Quality of Life After Radiotherapy for Rectal and Anal Cancer. Curr Colorectal Cancer Rep. 2020; 16(1): 1-10. doi:10.1007/s11888-019-00448-w.
10. Tetar SU, Bruynzeel AME, Oei SS, Senan S, Fraikin T, Slotman BJ et al. Magnetic Resonance-guided Stereotactic Radiotherapy for Localized Prostate Cancer: Final Results on Patient-reported Outcomes of a Prospective Phase 2 Study. Eur Urol Oncol. 2020. doi:10.1016/j.euo.2020.05.007.
11. Holch P, Pini S, Henry AM, Davidson S, Routledge J, Brown J et al. eRAPID electronic patient self-Reporting of Adverse-events: Patient Information and aDvice: a pilot study protocol in pelvic radiotherapy. Pilot Feasibility Stud. 2018; 4: 110. doi:10.1186/s40814-018-0304-6.
12. Chang P, Szymanski KM, Dunn RL, Chipman JJ, Litwin MS, Nguyen PL et al. Expanded prostate cancer index composite for clinical practice: development and validation of a practical health related quality of life instrument for use in the routine clinical care of patients with prostate cancer. J Urol. 2011; 186(3): 865-872. doi:10.1016/j.juro.2011.04.085.
13. Murthy V, Maitre P, Bhatia J, Kannan S, Krishnatry R, Prakash G et al. Late toxicity and quality of life with prostate only or whole pelvic radiation therapy in high risk prostate cancer (POP-RT): A randomised trial. Radiother Oncol. 2020; 145:71-80. doi:10.1016/j.radonc.2019.12.006.
14. Dy SM, Roy J, Ott GE, McHale M, Kennedy C, Kutner JS et al. Tell Us™: a Web-based tool for improving communication among patients, families, and providers in hospice and palliative care through systematic data specification, collection, and use. J Pain Symptom Manage. 2011; 42(4): 526-534. doi:10.1016/j.jpainsymman.2010.12.006.
15. Movsas B, Hunt D, Watkins-Bruner D, Lee WR, Tharpe H, Goldstein D et al. Can electronic web-based technology improve quality of life data collection? Analysis of Radiation Therapy Oncology Group 0828. Pract Radiat Oncol. 2014; 4(3): 187-191. doi:10.1016/j.prro.2013.07.014.
2. Digital health. World Health Organization. 2020. Available at: https://www.who.int/reproductivehealth/publications/mhealth/en/. Last accessed on : Aug 24 , 2020.
3. Advances in Patient Reported Outcomes: Integration and Innovation : Leeds, UK. 13 June 2019. J Patient Rep Outcomes. 2020; 4(1): 28. doi:10.1186/s41687-020-00193-x.
4. Niska JR, Thorpe CS, Halyard MY, Tan AD, Atherton PJ, Dueck AC et al. Patient-reported quality-of-life outcomes in relation to provider-assessed adverse events during head and neck radiotherapy. J Patient Rep Outcomes. 2020; 4(1): 60. doi:10.1186/s41687-020-00227-4.
5. DEGRO 2017: Growing demand for ePROM solutions within radio-oncology. © 2020 Kaiku Health. 2017. Available at: https://kaikuhealth.com/degro-2017-growing-demand-eprom-solutions-within-radio-oncology/. Last accessed on : Aug 20 , 2020.
6. Hauth F, Bizu V, App R, Lautenbacher H, Tenev A, Bitzer M et al. Electronic Patient-Reported Outcome Measures in Radiation Oncology: Initial Experience After Workflow Implementation. JMIR Mhealth Uhealth. 2019; 7(7): e12345. doi:10.2196/12345.
7. NCI-PRO-CTCAE™ ITEMS-RUSSIAN. Item Library Version 1.0. NATIONAL INSTITUTES OF HEALTH, in Bethesda, Maryland, U.S.A. Use of the PROCTCAE™ is subject to NCI’s Terms of Use. 2020. Available at: https://healthcaredelivery.cancer.gov/pro-ctcae/pro-ctcae_russian.pdf. Last accessed on : Aug 23 , 2020.
8. Pena-Hernandez C, Nugent K, Tuncel M. Twenty-Four-Hour Ambulatory Blood Pressure Monitoring. J Prim Care Community Health. 2020; 11:2150132720940519. doi:10.1177/2150132720940519.
9. Neibart SS, Manne SL, Jabbour SK. Quality of Life After Radiotherapy for Rectal and Anal Cancer. Curr Colorectal Cancer Rep. 2020; 16(1): 1-10. doi:10.1007/s11888-019-00448-w.
10. Tetar SU, Bruynzeel AME, Oei SS, Senan S, Fraikin T, Slotman BJ et al. Magnetic Resonance-guided Stereotactic Radiotherapy for Localized Prostate Cancer: Final Results on Patient-reported Outcomes of a Prospective Phase 2 Study. Eur Urol Oncol. 2020. doi:10.1016/j.euo.2020.05.007.
11. Holch P, Pini S, Henry AM, Davidson S, Routledge J, Brown J et al. eRAPID electronic patient self-Reporting of Adverse-events: Patient Information and aDvice: a pilot study protocol in pelvic radiotherapy. Pilot Feasibility Stud. 2018; 4: 110. doi:10.1186/s40814-018-0304-6.
12. Chang P, Szymanski KM, Dunn RL, Chipman JJ, Litwin MS, Nguyen PL et al. Expanded prostate cancer index composite for clinical practice: development and validation of a practical health related quality of life instrument for use in the routine clinical care of patients with prostate cancer. J Urol. 2011; 186(3): 865-872. doi:10.1016/j.juro.2011.04.085.
13. Murthy V, Maitre P, Bhatia J, Kannan S, Krishnatry R, Prakash G et al. Late toxicity and quality of life with prostate only or whole pelvic radiation therapy in high risk prostate cancer (POP-RT): A randomised trial. Radiother Oncol. 2020; 145:71-80. doi:10.1016/j.radonc.2019.12.006.
14. Dy SM, Roy J, Ott GE, McHale M, Kennedy C, Kutner JS et al. Tell Us™: a Web-based tool for improving communication among patients, families, and providers in hospice and palliative care through systematic data specification, collection, and use. J Pain Symptom Manage. 2011; 42(4): 526-534. doi:10.1016/j.jpainsymman.2010.12.006.
15. Movsas B, Hunt D, Watkins-Bruner D, Lee WR, Tharpe H, Goldstein D et al. Can electronic web-based technology improve quality of life data collection? Analysis of Radiation Therapy Oncology Group 0828. Pract Radiat Oncol. 2014; 4(3): 187-191. doi:10.1016/j.prro.2013.07.014.
For citation
Zavyalov A.A., Kashurnikov A.Y., Andreev D.A. Specialized electronic-based patient questionnaires for analysis of clinical outcomes in radiation oncology. Medical doctor and information technology. 2021; 2: 28-35. (In Russ.). doi: 1025881/18110193_2021_2_28.
Documents
Keywords