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MD&IT № 2 2024

Original Research

An empirical theory of the formation of emotional and volitional deficits in schizophrenia with a predominance of negative disorders, developed as a result of analysis of the relationship between clinical and genetic data with the JSM method for automated

The study attempted to test experts' assumptions about the difference in the genetic mechanisms of the formation of emotional and volitional deficits in schizophrenia with predominance of negative disorders. The aim of the study is to create empirical theory of these two phenomena using an approach based on JSM-method for automated research support (JSM-method ARS). Polymorphisms of four genes associated with schizophrenia (BDNF, 5HTR2A, HTTLPR, ZNF804A) and clinical data presented as PANSS score...